Heterophile test antibodies are sensitive and specific for EBV heterophile antibodies, they are present in peak levels weeks after primary. Paul Bunnell Test is used for detecting heterophil antibodies in infectious mononucleosis. This test uses sheep RBCs that are specially prepared. When these. The mononuclear spot test or monospot test, a form of the heterophile antibody test, is a rapid test for infectious mononucleosis due to Epstein–Barr virus (EBV).‎Medical uses · ‎Usefulness.


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Using 38 sera from patients with strong clinical and haematological evidence of infectious mononucleosis no false negative results were found with the Monospot test. Paul Bunnell Test is used for detecting heterophil antibodies in infectious mononucleosis.

Paul Bunnell Test

This test uses sheep RBCs that are specially prepared. When these clump or aggregates, then they are put in blood samples of patients with heterophile antibodies. The mixture is left undisturbed test de paul bunnell one minute not rocked or shaken.

Examine for the presence or absence of red cell agglutination. If stronger with the sera adsorbed with guinea-pig kidney, the test is negative.

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If stronger with the sera adsorbed with ox red cell stroma, the test is positive. The test de paul bunnell typically runs its course in four to six weeks in people with normally functioning immune systems.

People with weakened or suppressed immune systems, such as AIDS patients or those who have had organ transplants, are particularly vulnerable to the potentially serious complications of infectious mononucleosis.

Causes and symptoms The EBV that causes mononucleosis is test de paul bunnell to a group of herpes viruses, including those that cause cold sores, chicken pox, and shingles. Most people are exposed to EBV at some point during their lives.


Mononucleosis is most commonly spread by contact with virus-infected saliva through coughing, sneezing, kissing, or sharing drinking glasses or eating utensils.

In addition to general weakness and fatigue, symptoms of mononucleosis may include any or all of the following: Complications that can occur with mononucleosis include a temporarily enlarged spleen or test de paul bunnell liver.

In rare instances, the spleen may rupture, producing sharp pain on the left side of the abdomen, a symptom that warrants immediate medical attention.

Heterophile antibody test - Wikipedia

Additional symptoms of a ruptured spleen include light headedness, rapidly beating heart, and difficulty breathing. Other test de paul bunnell, but potentially life-threatening, complications may involve the heart or brain. The infection may also cause significant destruction of the body's red blood cells or platelets.

Symptoms do not usually appear until four test de paul bunnell seven weeks after exposure to EBV. An infected person can be contagious during this incubation time period and for as many as five months after the disappearance of symptoms.

Also, the virus will be excreted in the saliva intermittently for the rest of their lives, although the individual will experience no symptoms.

Paul-Bunnell test

Contrary to popular test de paul bunnell, the EBV is not highly contagious. As a result, individuals living in a household or college dormitory with someone who has mononucleosis have a very small risk of being infected unless they have direct contact with the test de paul bunnell saliva.

Diagnosis If symptoms associated with a cold persist longer than two weeks, mononucleosis is a possibility; however, a variety of other conditions can produce similar symptoms.

If mononucleosis is suspected, a physician will typically conduct a physical examinationincluding a "Monospot" antibody blood test that can indicate the presence of proteins or antibodies produced in response to infection with the EBV. These antibodies may not be detectable, however, until the second or third weeks of the illness.

Occasionally, when this test is inconclusive, other blood tests may be conducted.

Treatment The most test de paul bunnell treatment for infectious mononucleosis is rest and a gradual return to regular activities. Individuals with mild cases may not require bed rest but should limit their activities.

Any strenuous activity, athletic endeavors, or heavy lifting should be avoided until the symptoms completely subside, since excessive activity may cause the spleen to rupture.

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